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光谱法研究阿莫西林及其与DNA的相互作用
引用本文:康倩倩,周光明.光谱法研究阿莫西林及其与DNA的相互作用[J].光散射学报,2011,23(4):368-375.
作者姓名:康倩倩  周光明
作者单位:西南大学化学化工学院发光与实时分析教育部重点实验室,重庆,400715
基金项目:国家科技重大专项(2008ZX07315);重庆市自然科学基金(CSTC2007BB5370)
摘    要:报道了阿莫西林对照品与阿莫西林胶囊的常规拉曼光谱(NRS)和在银胶基底上溶液的表面增强拉曼光谱(SERS),归属了各个振动峰位和增强峰位;研究了阿莫西林对照品溶液与DNA相互作用的荧光光谱和表面增强拉曼光谱.结果表明:阿莫西林胶囊与阿莫西林对照品的NRS及SERS图谱基本一致,说明胶囊中的辅料对阿莫西林的检测几乎没有影...

关 键 词:拉曼光谱  表面增强拉曼光谱  荧光光谱  阿莫西林  DNA
收稿时间:2011/7/18

Study on Amoxicillin and the Interaction with DNA by Spectrometric Methods
KANG Qian-qian , ZHOU Guang-ming.Study on Amoxicillin and the Interaction with DNA by Spectrometric Methods[J].Chinese Journal of Light Scattering,2011,23(4):368-375.
Authors:KANG Qian-qian  ZHOU Guang-ming
Institution:(Key Laboratory on Luminescence and Real-Time Analysis(Southwest University),Ministry of Education,School of Chemistry and Chemical Engineering,Southwest University,Chongqing 400715,China)
Abstract:Normal Raman spectroscopy(NRS) and surface-enhanced Raman spectroscopy(SERS) of amoxicillin and amoxicillin capsule on the silver colloidal substrate were reported,and the vibrational and enhanced peaks were assigned;the interaction of amoxicillin and DNA were investigated by Fluorescence and SERS.The results showed that,NRS and SERS of amoxicillin and amoxicillin capsule were consistent basically,which indicated that excipient hardly affected the detection of amoxicillin;in SERS,amoxicillin were absorbed on silver colloid through the nitrogen atom and the benzene ring parallel;The interaction was mainly caused by the inserting-action mode between amoxicillin and DNA,and the benzene ring and the nitrogen atom of amoxicillin insert the base pair of the double helix structure of DNA,which provided important information and useful reference for understanding deeply the mechanism of action of this kind of drug.
Keywords:Raman  SERS  fluorescence  amoxicillin  DNA
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