| 竹红菌素及其衍生物敏化的生物膜和DNA结构的光损伤的Raman光谱研究 |
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| 引用本文： | 许以明,张志义.竹红菌素及其衍生物敏化的生物膜和DNA结构的光损伤的Raman光谱研究[J].光散射学报,1998,10(2):68-75. |
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| 作者姓名： | 许以明 张志义 |
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| 作者单位： | 中国科学院生物物理研究所 |
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| 摘 要： | 本文综述了具有抗癌和抗艾滋病毒活性的三种光敏剂—竹红菌素及其衍生物敏化的生物大分子—生物膜和ＤＮＡ结构的光损伤的Ｒａｍａｎ光谱特征；上述三种光敏剂对ＤＮＡ和生物膜损伤最强的均为５－Ｂｒ－ＨＢ，其次是ＨＢ，然后是ＨＡ，即５－Ｂｒ－ＨＢ＞ＨＢ＞ＨＡ。说明药物的结构与它的光敏活性密切相关，修饰结构是增进药效的重要途径。
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| 关 键 词： | 竹红菌甲素 乙素 5－Br－HB 生物膜 DNA 光损伤 敏化 Raman光谱 |
Raman Spectroscopic Study of Structural Photodamage of Biomembrane and DNA Sensitized By Hypocrellin and Its Derivatives |
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| Xu Yiming,Zhang Zhiyi.Raman Spectroscopic Study of Structural Photodamage of Biomembrane and DNA Sensitized By Hypocrellin and Its Derivatives[J].Chinese Journal of Light Scattering,1998,10(2):68-75. |
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| Authors: | Xu Yiming Zhang Zhiyi |
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| Abstract: | It is summary of Raman spectroscopic characteristics of photodamage's biomembrane and DNA sensitized by three hypocrellin and its derivatives having anticancer and antivirus activities. Photosensitive damage on biomembrane and DNA sensitized by 5 Br hypocrellin B(HB) is stronger than that by hypocrellin A (HA) and hypocrellin B(HB), that is, 5 Br HB>HB>HA. It was indicated that the structure of drug is close related to its photosensitive activity and the modification of structure of drug is one of important path which improves efficience of drug. |
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| Keywords: | hypocrellin and its derivatives biomembrane DNA photodamage Raman specroscopy |
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