| Raman光谱法与经典方法验证阿司匹林固体分散体 |
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| 引用本文： | 王玮,李晓曼,田京辉,席欣欣,程黎.Raman光谱法与经典方法验证阿司匹林固体分散体[J].光散射学报,2011,23(1):57-60. |
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| 作者姓名： | 王玮 李晓曼 田京辉 席欣欣 程黎 |
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| 作者单位： | 河南大学药学院,开封,475004 |
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| 摘 要： | 为了验证Raman光谱法验证固体分散体的可行性, 采用熔融法制备阿司匹林固体分散体, 并用Raman光谱法和经典方法(红外光谱法和X-射线衍射法)研究其分散性。三种鉴别方法得到一致的结果--阿司匹林以微晶状态分散在固体分散体中, 且拉曼光谱法简单易行、快速直接、对样品无损伤, 是一种新的理想的检查固体分散体分散性的方法。
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| 关 键 词： | 阿司匹林 固体分散体 拉曼光谱 红外光谱 X-射线衍射 |
| 收稿时间： | 2010/11/21 |
To Verify Aspirin Solid Dispersion by Vibration Spectrometry and X-ray Diffraction Method |
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| WANG Wei,LI Xiao-man,TIAN Jing-hui,XI Xin-xin,CHENG Li.To Verify Aspirin Solid Dispersion by Vibration Spectrometry and X-ray Diffraction Method[J].Chinese Journal of Light Scattering,2011,23(1):57-60. |
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| Authors: | WANG Wei LI Xiao-man TIAN Jing-hui XI Xin-xin CHENG Li |
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| Institution: | (Pharmaceutical College of Henan University,Kaifeng Henan,475004 China) |
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| Abstract: | Aspirin solid dispersion was prepared by melt method and was verified by Raman spectrometry and the classical methods(infrared spectrometry and X-ray powder diffractometry) in order to test the feasibility of Raman spectrometry in identifying solid dispersion.The three methods obtained the same results-Aspirin was dispersed in the carrier in the state of microcrystalline.Raman spectrometry,simple,fast,direct and non-destructive,is an ideal method in examining the dispersivity of solid dispersion. |
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| Keywords: | aspirin solid dispersion Raman spectroscopy infrared spectroscopy X-ray diffraction |
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