Interaction of biological and nonbiological surfaces. New opportunities for research and technologies using synchrotron radiation |
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Authors: | S M Bezruchko S M Kuzmin O V Sergeev N V Spinko |
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Institution: | 1.Lukin Research Institute for Physical Problems,Zelenograd, Moscow oblast,Russia |
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Abstract: | The applicability of synchrotron radiation to implementation of medical ideas associated with introduction of nonbiological
objects into a human body—implants, drug nanocapsules, and X-ray therapeutic means (metal nanoparticles and nanocrystalline
phosphors and scintillators)—is considered. Synchrotron radiation presents new possibilities of analyzing the surface with
a resolution comparable to the sizes of biological nanostructures involved in interactions such as chemical and biochemical
modification of implant surfaces in vitro; activation of implant surface integration with biological tissue in a tissue culture
(in vitro) and in vivo; biochemical modification of therapeutic nanoparticle surface in vitro; immunocamouflage by host proteins;
attachment of “molecular targets”, i.e., antibodies, to target tissue to provide targeted delivery vehicles; and local activation
of X-ray therapeutic drugs and drug nanocapsules in biological tissues. A functional block diagram of a medical technological
station is given. |
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