| X-ray diffraction enhanced imaging study of intraocular tumors in human beings |
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| 作者姓名： | 谈高 汪华侨 陈雨 袁清习 黎刚 张晓丹 朱佩平 钟秀风 唐劲天 |
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| 作者单位： | Department;Anatomy;Brain;Research;Biomedical;Engineering;Center;Zhongshan;School;Medicine;Yat-sen;University;Fifth;Affliated;Hospital;Laboratory;Particle;Radiation;Imaging;Education;Ministry;China;Physics;Tsinghua;Institute;High;Energy;Chinese;Academy;Sciences;First;State;Ophthalmology;Ophthalmic; |
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| 基金项目： | Supported by National Natural Science Foundation (10490195);;Key Project of Chinese National Programs for Fundamental Research and Development (973 program) (2006cb500700);;Natural Science and Technology Foundation of Guangdong Province(04009356,2008B030301320) |
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| 摘 要： | Diffraction enhanced imaging （DEI） with edge enhancement is suitable for the observation of weakly absorbing objects. The potential ability of the DEI was explored for displaying the microanatomy and pathology of human eyeball in this work. The images of surgical specimens from malignant intraocular tumor of hospitalized patients were taken using the hard X-rays from the topography station of Beamline 4W1A at Beijing Synchrotron Radiation Facility （BSRF）. The obtained radiographic images were analyzed in correlation with those of pathology. The results show that the anatomic and pathologic details of intraocular tumors in human beings can be observed clearly by DEI for the first time, with good visualization of the microscopic details of eyeball ring such as sclera, choroids and other details of intraocular organelles. And the best resolution of DEI images reaches up to the magnitude of several tens of μm. The results suggest that it is capable of exhibiting clearly the details of intraocular tumor using DEI method.
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| 关 键 词： | X射线衍射 恶性肿瘤 人类 成像 北京同步辐射装置 电子方法 图像分析 潜在能力 |
| 收稿时间： | 2009-4-14 |
| 修稿时间： | 2009-7-6 |
X-ray diffraction enhanced imaging study of intraocular tumors in human beings |
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| TAN Gao,WANG Hua-Qiao,CHEN Yu,YUAN Qing-Xi,LI Gang,ZHANG Xiao-Dan,ZHU Pei-Ping,ZHONG Xiu-Feng,TANG Jin-Tian.X-ray diffraction enhanced imaging study of intraocular tumors in human beings[J].High Energy Physics and Nuclear Physics,2010,34(2):237-244. |
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| Authors: | TAN Gao WANG Hua-Qiao CHEN Yu YUAN Qing-Xi LI Gang ZHANG Xiao-Dan ZHU Pei-Ping ZHONG Xiu-Feng TANG Jin-Tian |
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| Institution: | [1]Department of Anatomy and Brain Research, Biomedical Engineering Center, Zhongshan School of Medicine,Sun Yat-sen University, Guangzhou 510080, China [2]The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China [3]Key Laboratory of Particle ＆ Radiation Imaging, Education Ministry of China, Department of Engineering Physics, Tsinghua University, Beijing 100084, China [4]Institute of High Energy Physics, Chinese Acdemy of Sciences, Beijing 100049, China [5]The First Affiliated Hospital of Tsinghua University, Beijing 100016, China [6]The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510080, China |
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| Abstract: | Diffraction enhanced imaging(DEI) with edge enhancement is suitable for the observation of weakly absorbing objects.The potential ability of the DEI was explored for displaying the microanatomy and pathology of human eyeball in this work.The images of surgical specimens from malignant intraocular tumor of hospitalized patients were taken using the hard X-rays from the topography station of Beamline 4W1A at Beijing Synchrotron Radiation Facility(BSRF).The obtained radiographic images were analyzed in correla... |
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| Keywords: | diffraction enhanced imaging （DEI） intraocular malignant tumor synchrotron radiation X-ray phase-contrast imaging （XPCI） X-ray absorption contrast imaging （XACI） |
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