Gas-Generating,pH-Responsive Calcium Carbonate Hybrid Particles with Biomimetic Coating for Contrast-Enhanced Ultrasound Imaging |
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| Authors: | Mark Louis P Vidallon Alon M Douek Adam Quek Heather McLiesh Jan Kaslin Rico F Tabor Alexis I Bishop Boon Mian Teo |
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| Institution: | 1. School of Chemistry, Monash University, Clayton, VIC, 3800 Australia;2. Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, 3800 Australia;3. Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, 3800 Australia;4. BioPRIA, BioResource Processing Research Institute of Australia, Department of Chemical Engineering, Monash University, Clayton, VIC, 3800 Australia;5. School of Physics and Astronomy, Monash University, Clayton, VIC, 3800 Australia |
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| Abstract: | This work reports the fabrication of biocompatible and pH-sensitive hybrid polydopamine/bovine serum albumin/calcium carbonate (PDA/BSA/CaCO3) particles via a rapid precipitation method. These hybrid particles generate hyperechogenic carbon dioxide bubbles upon exposure to low pH environments, making them ideal as a contrast agent and detector for tumor cells. This study also highlights the application of red blood cell membrane (RBC)-derived membranes as a biomimetic coating for PDA/BSA/CaCO3 hybrid particles in order to modulate protein corona formation, a natural physiological response that alters tailored properties of most nanomaterials that are administered systemically. Results of this work demonstrate that the RBC membrane-coated hybrid particles are ideal for a wide range of biomedical applications, such as noninvasive multimodal imaging, photothermal and photodynamic therapy, and “personalized” drug delivery systems. |
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| Keywords: | calcium carbonate nanoparticles contrast enhanced ultrasound imaging protein corona red blood cell membranes |
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