Frequency-selective quantitation of short-echo time 1H magnetic resonance spectra |
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Authors: | Poullet Jean-Baptiste Sima Diana M Van Huffel Sabine Van Hecke Paul |
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Institution: | Department of Electrical Engineering, SCD-SISTA, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, 3001 Leuven, Belgium. jean-baptiste.poullet@esat.kuleuven.be |
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Abstract: | Accurate and efficient filtering techniques are required to suppress large nuisance components present in short-echo time magnetic resonance (MR) spectra. This paper discusses two powerful filtering techniques used in long-echo time MR spectral quantitation, the maximum-phase FIR filter (MP-FIR) and the Hankel-Lanczos Singular Value Decomposition with Partial ReOrthogonalization (HLSVD-PRO), and shows that they can be applied to their more complex short-echo time spectral counterparts. Both filters are validated and compared through extensive simulations. Their properties are discussed. In particular, the capability of MP-FIR for dealing with macromolecular components is emphasized. Although this property does not make a large difference for long-echo time MR spectra, it can be important when quantifying short-echo time spectra. |
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Keywords: | Magnetic resonance spectroscopy (MRS) Frequency-selective quantitation Finite impulse response (FIR) filter Automated quantitation of short-echo time MRS spectra (AQSES) Non-linear least-squares (NLLS) |
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