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Matrix assisted pulsed laser evaporation processing of triacetate-pullulan polysaccharide thin films for drug delivery systems |
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| Authors: | R Cristescu G Dorcioman E Axente A Moldovan T Kocourek M Albulescu D Mihaiescu DB Chrisey |
| Institution: | a National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor, P.O. Box MG-36, RO-077125, Bucharest-Magurele, Romania b Institute of Physics, Academy of Sciences of Czech Republic, Na Slovance 2, 182 21 Prague 8, Czech Republic c National Institute for Chemical-Pharmaceutical R&D, 112 Vitan, 74373 Bucharest 3, Romania d Petru Poni Institute of Macromolecular Chemistry, Iasi 6600, Romania e University of Agriculture Sciences and Veterinary Medicine, 59 Marasti, Bucharest, Romania f University of Bucharest, Faculty of Physics, P.O. Box MG-38, 3 Nano-SAE Research Center, Bucharest-Magurele, Romania g US Naval Research Laboratory, Washington, DC 20375-5345, USA |
| Abstract: | We report the first successful deposition of triacetate-pullulan polysaccharide thin films by matrix assisted pulsed laser evaporation. We used a KrF* excimer laser source (λ = 248 nm, τ ≈ 20 ns) operated at a repetition rate of 10 Hz. We demonstrated by FTIR that our thin films are composed of triacetate-pullulan maintaining its chemical structure and functionality. The dependence on incident laser fluence of the induced surface morphology is analysed. |
| Keywords: | Polysaccharide Pullulan Thin films Laser deposition Matrix assisted pulsed laser evaporation Drug delivery |
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