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Matrix assisted pulsed laser evaporation of cinnamate-pullulan and tosylate-pullulan polysaccharide derivative thin films for pharmaceutical applications
Authors:M Jelinek  R Cristescu  E Axente  J Dybal  J Plestil  M Albulescu  I Stamatin  DB Chrisey
Institution:a Institute of Physics ASCR, Na Slovance 2, 18221 Prague 8, Czech Republic
b Faculty of Biomedical Engineering CVUT, nam. Sitna 3105, 27201 Kladno, Czech Republic
c National Institute for Laser, Plasma and Radiation Physics, MG-36, RO-77125 Bucharest, Romania
d Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 16206 Prague 6, Czech Republic
e University of Agriculture Sciences and Veterinary Medicine, 59 Marasti, Bucharest, Romania
f Institute for Chemical-Pharmaceutical R&D, 112 Vitan, 74373 Bucharest 3, Romania
g Petru Poni Institute of Macromolecular Chemistry, Iasi 6600, Romania
h 3Nano-SAE Research Center, University of Bucharest, P.O. Box MG-38, Bucharest-Magurele, Romania
i Rensselaer Polytechnic Institute, Department of Material Science, 110 8th Street, Troy, NY 12180-3590, USA
Abstract:We have demonstrated the successful thin film growth of two pullulan derivatives (cinnamate-pullulan and tosylate-pullulan) using matrix assisted pulsed laser evaporation (MAPLE). Our MAPLE system consisted of a KrF* laser, a vacuum chamber, and a rotating target holder cooled with liquid nitrogen. Fused silica and silicon (1 1 1) wafers were used as substrates. The MAPLE-deposited thin films were characterized by transmission spectrometry, profilometry, atomic force microscopy (AFM), Fourier transform infrared (FTIR) spectroscopy and Raman spectroscopy. The deposited layers ranged from 250 nm to 16.5 μm in thickness, depending on the laser fluence (0.065-0.5 J cm−2) and number of pulses applied for the deposition of one structure (1500-13,300). Our results confirmed that MAPLE was well-suited for the transfer of cinnamate-pullulan and tosylate-pullulan.
Keywords:Drug delivery  Polysaccharide  Pullulan derivatives  Thin films  Matrix assisted pulsed laser evaporation
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