| (2R,5S)-N-间氟苄基-2,5-二甲基哌嗪的合成 |
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| 引用本文： | 赵钊,杨健.(2R,5S)-N-间氟苄基-2,5-二甲基哌嗪的合成[J].光谱实验室,2011,28(5):2370-2372. |
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| 作者姓名： | 赵钊 杨健 |
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| 作者单位： | 昆明理工大学生命科学与技术学院 昆明市白龙寺296号650224 |
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| 摘 要： | 以(2R,5S)-2,5-二甲基哌嗪为原料,经过成盐,单取代反应,用D-酉石酸对光学异构体的手性拆分,用氢氧化钠游离,最终合成(2R,5S)-N-间氟苄基-2,5-二甲基哌嗪,反应总收率为83％.该物质的合成未见文献报道,目标化合物用1H NMR,IR进行结构表征.
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| 关 键 词： | (2R 5S)-2 5-二甲基哌嗪f光学异构体 (2R 5S)-N-间氟苄基-2 5-二甲基哌嗪 |
Synthesis of(2R,5S)-2,5-Dimethyl-4-(3Fluorobenzyl) Piperazine |
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| ZHAO Zhao,YANG Jian.Synthesis of(2R,5S)-2,5-Dimethyl-4-(3Fluorobenzyl) Piperazine[J].Chinese Journal of Spectroscopy Laboratory,2011,28(5):2370-2372. |
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| Authors: | ZHAO Zhao YANG Jian |
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| Institution: | ZHAO Zhao YANG Jian(College of Life Science and Technology,Kunming University of Science and Technique,Kunming 650224,P.R.China) |
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| Abstract: | (2R,5S)-2,5-Dimethyl-4-(3-fluorobenzyl)piperazine was synthesized from (2R,5S)-2,5-Dimethylpiperazine by salification,monosubstitution reaction,and separated by D-tartaric acid,then the tartrate was resoluted by NaOH.Overall yield was 83%.The product was not reported in literatures.The structure of the target compound were characterized by IR and 1H NMR. |
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| Keywords: | (2R 5S)-2 5-Dimethylpiperazine Optical Isomers 5-Dimethyl-4-(3-Fluorobenzyl) Piperazine |
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