| 分光光度法测定阿奇霉素囊泡中的药物含量 |
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| 引用本文： | 王红,谭群友,钟萌,廖红,张景勍.分光光度法测定阿奇霉素囊泡中的药物含量[J].光谱实验室,2011,28(6):2803-2806. |
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| 作者姓名： | 王红 谭群友 钟萌 廖红 张景勍 |
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| 作者单位： | 1. 重庆医科大学药物高校工程研究中心和生物化学与分子药理学重点实验室 重庆市渝中区医学院路1号400016
2. 第三军医大学大坪医院野战外科研究所胸外科 重庆市渝中区长江支路10号400042 |
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| 基金项目： | 国家自然科学基金项目(30973645); 重庆市教育委员会资助项目(首批高等学校优秀人才资助,KJ090308) |
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| 摘 要： | 建立测定阿奇霉素囊泡中药物含量的方法。采用分光光度法,用浓度为75%的硫酸作为显色剂,测定阿奇霉素囊泡中药物含量。阿奇霉素在482nm处有最大吸收,浓度在15—45μg.mL-1范围内与吸光度呈良好的线性关系,回归方程为：A=0.0168C-0.0182,r=0.9999（n=3）。该法操作简便、快速,重现性好,结果准确可靠,可用于阿奇霉素囊泡中药物含量的测定。
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| 关 键 词： | 分光光度法 阿奇霉素 囊泡 |
Determination of Drug in Azithromycin Niosomes by Spectrophotometry |
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| WANG Hong,TAN Qun-You,ZHONG Meng,LIAO Hong,ZHANG Jing-Qing.Determination of Drug in Azithromycin Niosomes by Spectrophotometry[J].Chinese Journal of Spectroscopy Laboratory,2011,28(6):2803-2806. |
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| Authors: | WANG Hong TAN Qun-You ZHONG Meng LIAO Hong ZHANG Jing-Qing |
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| Institution: | WANG Hong TAN Qun-Youa ZHONG Meng LIAO Hong ZHANG Jing-Qing(Medicine Engineering Research Center,Chongqing Key Laboratory of Biochemical & Molecular Pharmacology,Chongqing Medical University,Chongqing 400016,P.R.China)a(Center of Thoracic Surgery,Daping Hospital & Research Institute of Surgery,Third Military Medical University,Chongqing 400042,P.R.China) |
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| Abstract: | The method for determination of drug in azithromycin niosomes by spectrophotometry was developed.The drug contents of azithromycin were determined at 482nm with 75% sulfuric acid as the colour developing agent.The calibration curve of azithromycin was linear in range of 15—45μg·mL-1,and the regression equation was as follows：A=0.0168C-0.0182,r=0.9999（n=3）.The method is easy to operate,highly accurate and reliable in results,and that can be used to determine the content of drug in azithromycin niosomes. |
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| Keywords: | Spectrophotometry Azithromycin Niosomes |
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