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| 超高效液相色谱和质谱联用在药物研究领域的应用 | |
| 引用本文： | 黄昆,王文辉,李宝才,王齐,杨俊,李晚谊.超高效液相色谱和质谱联用在药物研究领域的应用[J].光谱实验室,2009,26(4):922-930. |
| 作者姓名： | 黄昆 王文辉 李宝才 王齐 杨俊 李晚谊 |
| 作者单位： | 1. 昆明理工大学分析测试研究中心,昆明市学府路253号,650093;昆明理工大学生命科学与技术学院,昆明市,650093 2. 昆明理工大学分析测试研究中心,昆明市学府路253号,650093 3. 昆明理工大学生命科学与技术学院,昆明市,650093 4. 云南省农业科学院,昆明市,650093 |
| 摘 要： | 超高效液相色谱（UPLC）在分离能力、灵敏度和专属性等方面有着巨大优势,与质谱（MS）联用后可以展现出强大的定性、定量分析能力,并已经在药物研究的各领域得到广泛应用。本文综述近年来超高效液相色谱和质谱联用（UPLC-MS）在药物研究领域应用取得的成果,着重介绍在药代动力学、药物成分分析、药物活性筛选研究等方面的应用。 |
| 关 键 词： | 超高效液相色谱-质谱联用技术 药代动力学 药物成分分析 药物筛选 |
Applications of Combined Ultra-High Performance Liquid Chromatography (UPLC) and Mass Spectrometry (MS)in the Field of Drug Research |
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| Huang Kun,Wang Wen-Hui,LI Bao-Cai,Wang Qi,Yang Jun,LI Wan-Yi.Applications of Combined Ultra-High Performance Liquid Chromatography (UPLC) and Mass Spectrometry (MS)in the Field of Drug Research[J].Chinese Journal of Spectroscopy Laboratory,2009,26(4):922-930. | |
| Authors: | Huang Kun Wang Wen-Hui LI Bao-Cai Wang Qi Yang Jun LI Wan-Yi |
| Institution: | HUANG Kun, WANG Wen-Hui, LI Bao-Cai, WANG Qi, YANG Jun, LI Wan-Yi (1.Research Center for Analysis and Measurement, Kunming University of Science and Technology ,Kunming 650093 ,P. R. China; 2.College of Life Science and Technology,Kunming University of Science and Technology,Kunming 650093 ,P. R. China; 3.Yunnan Agricaltural Academy,Kunming 650093,P. R. China) |
| Abstract: | Ultra-high performance liquid chromatography（UPLC） in the capacity of separation,sensitivity and specificity have great advantages,and mass spectrometry （MS） can be combined to show strong qualitative and quantitative analysis capabilities,and they have been found widespread application in all drug research.This paper reviews recent years,ultra-high performance liquid chromatography and mass spectrometry（UPLC-MS） applications in the field of drug research achievements highlighted in pharmacokinetics,drug analysis, drug activity, such as screening studies for the application. |
| Keywords: | UPLC-MS Pharmacokinetics Drug Component Analysis Screening of Drug Activity |
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