| 两种新型二氯代苯基卟啉-5-氟尿嘧啶衍生物的合成与表征 |
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| 引用本文： | 马红,韩士田,刘彦钦.两种新型二氯代苯基卟啉-5-氟尿嘧啶衍生物的合成与表征[J].光谱实验室,2010,27(1):234-237. |
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| 作者姓名： | 马红 韩士田 刘彦钦 |
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| 作者单位： | 河北师范大学化学与材料科学学院石家庄市裕华区槐北路113号,050016 |
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| 基金项目： | 国家自然科学基金(20601007);;河北省自然科学基金资助项目(203147);;河北省教育厅科学研究资助项目(2001120) |
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| 摘 要： | 用5-4-(5-溴戊氧基)苯基]-10,15,20-三(3,4-二氯苯基)卟啉或5-4-(6-溴己氧基)苯基]-10,15,20-三(3,4-二氯苯基)卟啉与5-氟尿嘧啶反应,合成了1-5-(4-戊氧苯基)-10,15,20-三(3,4-二氯苯基)卟啉]-5-氟尿嘧啶(A)和1-5-(4-己氧苯基)-10,15,20-三(3,4-二氯苯基)卟啉]-5-氟尿嘧啶(B),产率分别为29.92%和30.01%。并通过红外光谱、紫外可见光谱、核磁共振谱和质谱表征了其结构。对目标化合物的合成条件进行了研究,结果表明:以DMF为溶剂,反应温度为115℃,反应时间2h,产率较高;采用硅胶G(200—300目)装柱,以氯仿和氯仿∶乙醚(V∶V=50∶1)为洗脱液,柱层析,再用氯仿:丙酮(V∶V=7∶1)洗脱产品色带,分离效果较好。
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| 关 键 词： | 卟啉 合成 5-氟尿嘧啶 结构表征 |
Synthesis and Characterization of Two New Dichloro-Phenyl Porphyrin-5-Fluorouracil Compounds |
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| MA Hong,HAN Shi-Tian,LIU Yan-Qin.Synthesis and Characterization of Two New Dichloro-Phenyl Porphyrin-5-Fluorouracil Compounds[J].Chinese Journal of Spectroscopy Laboratory,2010,27(1):234-237. |
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| Authors: | MA Hong HAN Shi-Tian LIU Yan-Qin |
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| Institution: | College of Chemistry and Material Sciences;Hebei Normal University;Shijiazhuang 050016;P.R.China |
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| Abstract: | 1-5-(4-pentaphenoxy)phenyl-10,15,20-tri(3,4-dichlorophenyl)porphyrin]-5-fluorouracil(A),1-5-(4-hexaphenoxy)phenyl-10,15,20-tri(3,4-dichlorophenyl)porphyrin]-5-fluorouracil(B)were synthesized from 5-4-(5-bromo-pentaphenoxy)phenyl]-10,15,20-tri(3,4-dichlorophenyl)porphyrin or 5-4-(6-bromo-hexaphenoxy)phenyl]-10,15,20-tri(3,4-dichlorophenyl)porphyrin,and characterized by UV-Vis,IR,1HNMR and MS.The synthesis and separation conditions of the target compounds were studied.The yields were higher with DMF as th... |
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| Keywords: | Porphyrin Synthesis 5-Fluorouracil Structural Characterization |
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