| 紫外分光光度法测定奥氮平片的溶出度 |
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| 引用本文： | 杨莲华,潘耀,张友婷.紫外分光光度法测定奥氮平片的溶出度[J].光谱实验室,2013(6):3302-3305. |
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| 作者姓名： | 杨莲华 潘耀 张友婷 |
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| 作者单位： | 温州医学院附属第二医院药剂科,浙江省温州市学院西路109号325000 |
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| 摘 要： | 建立测定奥氮平片溶出度的方法.采用紫外分光光度法,以0.1mol/L盐酸为溶媒,溶媒体积500mL,转速50r/min,30min取样,在259nm波长处测定其溶出度.奥氮平片检测浓度的线性范围为3-20μg/mL （r=0.9994）平均回收率100.14％ （RSD=0.85％）,3批样品30min溶出度均在90％以上.方法简便、准确,结果可靠,可用于该制剂的溶出度测定.
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| 关 键 词： | 奥氮平片 溶出度 紫外分光光度法 |
Solubility Determination of Olanzapine Tablets by Ultraviolet Spectrophotometry |
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| YIAN Lian-Hua,PAN Yao,ZHANG You-Ting.Solubility Determination of Olanzapine Tablets by Ultraviolet Spectrophotometry[J].Chinese Journal of Spectroscopy Laboratory,2013(6):3302-3305. |
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| Authors: | YIAN Lian-Hua PAN Yao ZHANG You-Ting |
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| Institution: | (The Secured Hospital Affiliated to Wenzhou Medical College, Wenzhou, Zhejiang 325000 ,P. R. China) |
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| Abstract: | Method of olanzapine tablets solubility determination was establish. Ultraviolet spectrophotometry was used, with 0. lmol/L hydrochloric acid as solvent, solvent volume 500mL, speed 50r/min, 30 min sampling. Its solubility was determined in the 259nm wavelength. The linear range of detection concentration of olanzapine was 3-20μg/mL （r=0. 9994）, the average recovery was 100.14% （RSD=0.85%）, solubility of 30 rain for 3 batch samples was more than 90%. This method is simple, accurate, reliable, and can be used for the solubility determination of the preparation |
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| Keywords: | Olanzapine Solubility UV Spectrophotometry |
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