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| 响应面法优化超声提取熟地黄中5-羟甲基糠醛的工艺 | |
| 引用本文： | 曾令峰,沈建伟,王环,张本印,张学平,张晓峰.响应面法优化超声提取熟地黄中5-羟甲基糠醛的工艺[J].光谱实验室,2011,28(3):1261-1266. |
| 作者姓名： | 曾令峰 沈建伟 王环 张本印 张学平 张晓峰 |
| 作者单位： | 1. 中国科学院西北高原生物研究所,西宁市城西区西关大街59号,810008;中国科学院研究生院,北京市,100049 2. 中国科学院西北高原生物研究所,西宁市城西区西关大街59号,810008 3. 青海夏都医药有限公司,西宁市,810003 |
| 摘 要： | 采用响应面法优化了超声提取熟地黄中5-羟甲基糠醛的工艺.选取提取时间、溶剂浓度和温度3个因素为随机因子,在单因素的基础上进行3因素3水平Box-Behnken中心组合试验设计,以5-羟甲基糠醛得率为响应值进行响应面分析.优化后的超声提取熟地黄中5-羟甲基慷醛的条件为:在提取时间61.6min,溶剂体积分数90.5%,提... |
| 关 键 词： | 响应面法 超声提取 熟地黄 5-羟甲基糠醛 |
Optimization of Ultrasonic Extraction of 5-Hydroxymethylfurfural from Steamed Rehmanniae Radix by Response Surface Methodology |
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| ZENG Ling-Fenga,b SHEN Jian-Weia WANG Huana ZHANG Ben-Yina,bZHANG Xue-Pingc ZHANG Xiao-Feng.Optimization of Ultrasonic Extraction of 5-Hydroxymethylfurfural from Steamed Rehmanniae Radix by Response Surface Methodology[J].Chinese Journal of Spectroscopy Laboratory,2011,28(3):1261-1266. | |
| Authors: | ZENG Ling-Fenga b SHEN Jian-Weia WANG Huana ZHANG Ben-Yina bZHANG Xue-Pingc ZHANG Xiao-Feng |
| Institution: | aa(Institute of Northwest Plateau Biology,Chinese Academy of Sciences,Xining 810008,P.R.China)b(Graduate University of Chinese Academy of Sciences,Beijing 100049,P.R.China)c(Qinghai Xiadu Pharmaceuticals Corporation,Xining 810003,P.R.China) |
| Abstract: | Ultrasonic extraction of 5-hydroxymethylfurfural（5-HMF） from steamed Rehmanniae Radix was optimized by response surface methodology.Three factors three levers Box-Behnken design was employed to optimize the extraction process including extraction time,solvent concentration and extraction temperature as the three random factors.The extraction conditions after optimization were as follows：extraction time of 61.6min,methanol concentration of 90.5% and extraction temperature of 53.9℃.The relative error between the predictive yield（0.3403%） of 5-HMF under optimized conditions and results of the verification experiments（0.3389%） was only 0.4%,which indicated that the optimized method was feasible. |
| Keywords: | Response Surface Methodology Ultrasonic Extraction Steamed Rehmanniae Radix 5-Hydroxymethylfurfural |
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