| 茜素分光光度法测定磷霉素钠 |
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| 引用本文： | 刘一鸣,郭俊俊,马啸,宣春生.茜素分光光度法测定磷霉素钠[J].光谱实验室,2010,27(4):1329-1331. |
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| 作者姓名： | 刘一鸣 郭俊俊 马啸 宣春生 |
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| 作者单位： | 1. 山西省分析测试中心,太原市小店区平阳路北园街17号,030006
2. 太原理工大学煤科学与技术教育部和山西省重点实验室,太原市,030024 |
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| 摘 要： | 在乙醇体系中,磷霉素钠与茜素发生反应,生成稳定的1∶1的络合物,溶液颜色发生明显改变,其最大吸收波长为545nm,磷霉素钠的浓度在1.4—60mg·L-1范围内遵守比耳定律,表观摩尔吸光系数ε=3.47×103L·mol-1.cm-1,基于以上反应,本方法测定药物制剂含量与文献方法一致,回收率在99.6%—100.5%之间,结果满意。
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| 关 键 词： | 分光光度法 磷霉素钠 茜素 |
Determination of Dissolution of Fosfomycin Sodium by Spectrophotometry with Alizarin |
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| LIU Yi-Ming,Guo Jun-Jun,MA Xiao,XUAN Chun-Sheng.Determination of Dissolution of Fosfomycin Sodium by Spectrophotometry with Alizarin[J].Chinese Journal of Spectroscopy Laboratory,2010,27(4):1329-1331. |
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| Authors: | LIU Yi-Ming Guo Jun-Jun MA Xiao XUAN Chun-Sheng |
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| Institution: | a(Shanxi Analysing and Testing Center,Taiyuan 030006,P.R.China) a(Key Laboratory of Coal Science and Technology of Ministry of Education,Shanxi Province and Taiyuan University of Technology,Taiyuan 030024,P.R.China) |
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| Abstract: | A new spectrophotometric method was developed for the determination of fosfomycin sodium based on formation of 1：1 charge transfer complex with alizarin in ethanol solution.The complex maximum absorption is at 545nm The apparent molar absorptivity is 3.47×103L·mol-1·cm-1.The calibration curves are linear in the concentration range of 1.4—60mg·L-1.This proposed method has been applied to determination of fosfomycin sodium with satisfactory results.The recovery is 99.6%—100.5%. |
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| Keywords: | Spectrophotometry Fosfomycin Sodium Alizarin |
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