| 系列甲基苯基卟啉-5-氟尿嘧啶化合物的合成与表征 |
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| 引用本文： | 马红,李晓丽,刘彦钦,韩士田.系列甲基苯基卟啉-5-氟尿嘧啶化合物的合成与表征[J].光谱实验室,2010,27(5):1992-1996. |
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| 作者姓名： | 马红 李晓丽 刘彦钦 韩士田 |
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| 作者单位： | 1. 河北师范大学化学与材料科学学院,石家庄市裕华区槐北路113号,050016
2. 河北地质职工大学,石家庄市中山西路891号,050081 |
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| 基金项目： | 国家自然科学基金，河北省自然科学基金资助项目，河北省教育厅科学研究资助项目 |
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| 摘 要： | 设计合成了6种甲基苯基卟啉-5-氟尿嘧啶化合物。通过红外光谱、紫外-可见光谱、核磁共振谱和质谱对所合成的化合物结构进行了确认。探索出了合成反应的最佳条件和目标化合物的分离纯化方法。实验结果表明,选择DMF为溶剂,反应温度在115℃,反应时间2h,产率较高,A1、A2,B1、B2、C1和C2分别为25.66%、25.02%,24.89%、26.17%、28.43%和24.19%;采用硅胶G(粒径为48—75μm)柱层析,分离效果较好。
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| 关 键 词： | 5-氟尿嘧啶 卟啉 合成 表征 |
Synthesis and Characterization of Series Methylphenyl Porphyrin-5-Fluorouracil Compounds |
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| MA Hong,LI Xiao-Li,LIU Yan-Qin,HAN Shi-Tian.Synthesis and Characterization of Series Methylphenyl Porphyrin-5-Fluorouracil Compounds[J].Chinese Journal of Spectroscopy Laboratory,2010,27(5):1992-1996. |
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| Authors: | MA Hong LI Xiao-Li LIU Yan-Qin HAN Shi-Tian |
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| Institution: | (College of Chemistry and Material Sciences,Hebei Normal University,Shijiazhuang 050016,P.R.China)a(Hebei Vocational College of Geology,Shijiazhuang 050081,P.R.China) |
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| Abstract: | Six new methylphenyl porphyrin-5-fluorouracil compounds were synthesized and their structures were characterized by UV-Vis,IR,1H NMR and MS.The synthesis and separation conditions of the target compounds were studied.The results showed that the yield was higher when DMF was used as the solvent at 115℃ for 2h.The yields of A1,A2,B1,B2,C1,C2 were 25.66%,25.02%,24.89%,26.17%,28.43%,24.19% respectively.The products were separated via column chromatography with silica gel G（particle size 48—75μm）,and the separated effect was satisfactory. |
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| Keywords: | 5-Fluorouracil Porphyrin Synthesis Characterization |
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