| 5-N-甲基化苯并呋喃[3,2-b]喹啉衍生物的合成及其与小牛胸腺DNA相互作用 |
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| 引用本文： | 卢宇靖,张瑞瑞,杜志云,方岩雄,张焜.5-N-甲基化苯并呋喃[3,2-b]喹啉衍生物的合成及其与小牛胸腺DNA相互作用[J].光谱实验室,2011,28(4):1565-1569. |
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| 作者姓名： | 卢宇靖 张瑞瑞 杜志云 方岩雄 张焜 |
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| 作者单位： | 广东工业大学轻工化工学院 广州市广州大学城外环西路100号 510006 |
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| 基金项目： | 国家自然科学基金(21042003) |
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| 摘 要： | 设计并合成了天然产物喹叨啉(Quindoline)的两个衍生物:苯并呋喃3,2-b]喹啉和5-N-甲基苯并呋喃3,2-b]喹啉,通过MS、1H NMR等手段确认其结构.运用紫外(可见光谱、荧光光谱和圆二色光谱研究了合成的衍生物与小牛胸腺DNA结合能力的强弱和结合方式.实验结果表明,5-N季铵化引入的正电荷能提高苯并...
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| 关 键 词： | 苯并呋喃[3 2-b]喹啉 小牛胸腺DNA 荧光光谱 圆二色光谱 |
Synthesis of 5-N-methylated Benzofuro [3,2-b] Quinoline Derivatives and Interaction Between Derivatives and Calf Thymus DNA |
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| LU Yu-Jing,ZHANG Rui-Rui,DU Zhi-Yun,FANG Yan-Xiong,ZHANG Kun.Synthesis of 5-N-methylated Benzofuro [3,2-b] Quinoline Derivatives and Interaction Between Derivatives and Calf Thymus DNA[J].Chinese Journal of Spectroscopy Laboratory,2011,28(4):1565-1569. |
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| Authors: | LU Yu-Jing ZHANG Rui-Rui DU Zhi-Yun FANG Yan-Xiong ZHANG Kun |
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| Institution: | LU Yu-Jing ZHANG Rui-Rui DU Zhi-Yun FANG Yan-Xiong ZHANG Kun(Faculty of Chemical Engineering and Light Industry,Guangdong University of Technology,Guangzhou 510006 P.R.China) |
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| Abstract: | The two natural products quindoline derivatives,benzofuroquinoline and 5-N-methyl benzofuroquinoline,were synthesized,and their structures were characterized by MS and 1H NMR.The binding mode and binding ability of these derivatives with calf thymus DNA were studied by UV-Vis absorption spectra,fluorescence spectra and circular dichroism spectra.The introduction of a positive charge by N-methylation at 5-N position significantly improved the binding ability of derivatives and calf thymus DNA.Results from ci... |
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| Keywords: | BenzofuroQuinoline Calf Thymus DNA Fluorescence Spectra Circular Dichroism Spectra |
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