| 荧光光谱法研究头孢呋辛酯与牛血清白蛋白的相互作用 |
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| 引用本文： | 彭博,严拯宇,邵秀芬,赵靖天,周斌,胡育筑.荧光光谱法研究头孢呋辛酯与牛血清白蛋白的相互作用[J].光谱实验室,2005,22(5):913-916. |
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| 作者姓名： | 彭博 严拯宇 邵秀芬 赵靖天 周斌 胡育筑 |
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| 作者单位： | 中国药科大学分析化学教研室E-08信箱,南京市,210038;中国药科大学分析化学教研室E-08信箱,南京市,210038;中国药科大学分析化学教研室E-08信箱,南京市,210038;中国药科大学分析化学教研室E-08信箱,南京市,210038;中国药科大学分析化学教研室E-08信箱,南京市,210038;中国药科大学分析化学教研室E-08信箱,南京市,210038 |
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| 基金项目： | 国家自然科学基金资助项目(20375046) |
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| 摘 要： | 用荧光光谱法研究了头孢呋辛酯(Cefuroximeaxetil)与牛血清白蛋白(BSA)的相互作用机制。结果表明在人体生理条件下头孢呋辛酯对牛血清白蛋白具有荧光猝灭作用且为动态猝灭过程,根据Stern-Volmer方程求出了两者的猝灭常数,并依据Foster能量转移理论确定了药物与蛋白的结合距离。
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| 关 键 词： | 头孢呋辛酯 牛血清白蛋白 荧光光谱法 |
| 文章编号： | 1004-8138(2005)05-0913-04 |
| 收稿时间： | 2005-05-19 |
| 修稿时间： | 2005年5月19日 |
Interaction between Cefuroxime Axetil and Bovine Serum Albumin by Fluorescence Spectroscopy |
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| PENG Bo,YAN Zheng-Yu,SHAO Xiu-Fen,ZHAO Jing-Tian,ZHOU Bin,HU Yu-Zhu.Interaction between Cefuroxime Axetil and Bovine Serum Albumin by Fluorescence Spectroscopy[J].Chinese Journal of Spectroscopy Laboratory,2005,22(5):913-916. |
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| Authors: | PENG Bo YAN Zheng-Yu SHAO Xiu-Fen ZHAO Jing-Tian ZHOU Bin HU Yu-Zhu |
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| Institution: | China Pharmaceutical University , Nan jing 210038,P. R. China |
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| Abstract: | The interaction between Cefuroxime axetil and BSA was studied by fluorescence spectroscopy.It shows that the dynamic quenching exits between Cefuroxime axetil and BSA in physiological solution.Based on the equation of Stern-Volmer,the quenching constant was obtained.According to the Foster dipole-dipole energy transfer,the distance between Cefuroxime axetil and BSA was obtained as 3.16nm. |
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| Keywords: | Cefuroxime Axetil Bovine Serum Albumin Fluorescence Spectroscopy |
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