| 紫外分光光度法测定阿霉素聚乳酸微球的含量 |
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| 引用本文： | 吴景梅,邰燕芳,秦英月.紫外分光光度法测定阿霉素聚乳酸微球的含量[J].光谱实验室,2011,28(4):1940-1942. |
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| 作者姓名： | 吴景梅 邰燕芳 秦英月 |
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| 作者单位： | 蚌埠学院应用化学与环境工程系 安徽省蚌埠市曹山路1866号233030 |
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| 摘 要： | 采用复乳-溶剂挥发法制备阿霉素聚乳酸微球,通过扫描电镜观察微球的形态,采用紫外分光光度法测定徽球中阿霉素的含量.结果表明,所制备的阿霉素聚乳酸微球外形圆整,阿霉素溶液在1.70-34.1μg/mL浓度范围内线性良好,校准曲线回归方程为A=0.0422C+0.1845,相关系数r为0.9997,平均回收率为99.5%(R...
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| 关 键 词： | 乳化溶剂挥发法 阿霉素 聚乳酸微球 紫外分光光度法 |
Determination of Adriamycin in Polylactic Acid Microballoon by Ultraviolet Spectrophotometry |
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| WU Jing-Mei,TAI Yan-Fang,QIN Ying-Yue.Determination of Adriamycin in Polylactic Acid Microballoon by Ultraviolet Spectrophotometry[J].Chinese Journal of Spectroscopy Laboratory,2011,28(4):1940-1942. |
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| Authors: | WU Jing-Mei TAI Yan-Fang QIN Ying-Yue |
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| Institution: | WU Jing-Mei TAI Yan-Fang QIN Ying-Yue(Department of Applied Chemistry and Environmental Engineering,Bengbu College,Bengbu,Anhui 233030,P.R.China) |
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| Abstract: | Adriamycin polylactic acid microballoon was prepared with double emulsion-solvent evaporation technique,and the shape of the microballoon characterized by scanning electron microscopy（SEM）.The concentration of adriamycin in the microballon was analyzed by ultraviolet spectrophotometry.The results showed that the microballoon had smooth spherical surfaces.The linearity of adriamycin was better in the range of 1.70 to 34.1μg/mL,A=0.0422C＋0.1845,r=0.9997.The average recovery was 99.5%（RSD=0.50%）. |
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| Keywords: | Emulsion-Solvent Evaporation Technique Adriamycin Polylactic Acid Microballoon Ultraviolet Spectrophotometry |
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