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海藻酸钠/聚乳酸半互穿网络水凝胶的制备及溶胀性能研究
引用本文:姚伯龙,李倩,马鑫,倪才华.海藻酸钠/聚乳酸半互穿网络水凝胶的制备及溶胀性能研究[J].光谱实验室,2009,26(1):119-121.
作者姓名:姚伯龙  李倩  马鑫  倪才华
作者单位:江南大学化学与材料工程学院,江苏省无锡市蠡湖大道1800号,214122
摘    要:为了提高海藻酸钠对疏水性药物的负载量和缓释作用,将海藻酸钠与聚乳酸混合后分散于NaCl/CaCl2的混合溶液中制成半互穿网络水凝胶,对海藻酸钠进行了疏水改性,对该凝胶的溶胀度及pH敏感性进行了测试,进行了药物布洛芬包埋释放实验。考察了不同相对分子质量和用量的聚乳酸对药物释放的影响。结果表明,聚乳酸疏水改性后的海藻酸钠凝胶微球对药物布洛芬的负载量提高,具有较好的缓释作用。

关 键 词:海藻酸钠  疏水改性  控制释放

Preparation of Semi-Interpenetrating Polymer Network Hydrogel of Sodium Alginate/Polylactic Acid and Its Property
YAO Bo-Long,LI Qian,MA Xin,NI Cai-Hua.Preparation of Semi-Interpenetrating Polymer Network Hydrogel of Sodium Alginate/Polylactic Acid and Its Property[J].Chinese Journal of Spectroscopy Laboratory,2009,26(1):119-121.
Authors:YAO Bo-Long  LI Qian  MA Xin  NI Cai-Hua
Institution:School of Chemical and Material Engineering;Jiangnan University;Wuxi;Jiangsu 214122;P.R.China
Abstract:In order to improve the loading and release activity of sodium alginate,hydrophobic modification to alginate was made by mixing alginate with polyactic acid and NaCl/CaCl2 solution to forms a semi-interpenetrating polymer network.The swelling property and pH sensitivity of the hydrogel was studied as well as the embedment and controlled release experiments were carried out.The effects of mass and loading amount on the controlled release were studied.The modified microsphere of alginate hydrogel has increase...
Keywords:Sodium Algenate  Modification of Hydrophobic Property  Controlled Release    
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