物理因素对磷脂酰胆碱单分子层影响的研究

利用LB技术,在不同的物理条件下对磷脂酰胆碱单分子成膜质量和分子的构象变化进行了研究,在此础上对磷脂酰胆碱和胆固醇组成的复合膜的相变过程进行了研究,利用AFM对磷脂酰胆碱分子LB膜的分子构象和二维排布进行了表征.研究结果表明,物理因素温度、pH、浓度及胆固醇对于气液界面上磷脂酰胆碱的分子构象的结构有较大的影响.通过选择合适的条件能够得到具有特殊形态和结构的磷脂酰胆碱LB膜.

Influence physical factors on phosphatidylcholine monolayer film

Phosphatidylcholine monolayer films are studied under different physics conditions by LB technique.Meanwhile,analyze the quality of deposition monolayers and molecules' orientations. Base on this,we also studied the phase separation of complex consisting of phosphatidylcholine and cholesterol.By AFM,we character the molecular structure and orientations.The results show that the formation of phosphatidylcholine monolayer film is related to the physics conditions including density,temperature,pH,phosphatidylcholine molecule can form complexes with Cholesterol.We can obtain the specific structure of LB monolayers by choosing proper conditions.