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中性/聚电解质高分子混合刷对蛋白质的吸附/解吸附
引用本文:赵新军,陈九智,马超.中性/聚电解质高分子混合刷对蛋白质的吸附/解吸附[J].原子与分子物理学报,2020,37(2):177-184.
作者姓名:赵新军  陈九智  马超
作者单位:伊犁师范学院,新疆维吾尔自治区人民医院,伊犁师范学院
摘    要:本文应用分子理论,研究中性(A)/聚电解质(B)高分子混合刷对蛋白质的吸附/解吸附特性.理论模型考虑蛋白质与中性高分子A的排斥、以及与聚电解质高分子B的静电吸引.研究发现,在pH=4~6、中性高分子A处于弱水合状态时,混合刷中A高分子链塌缩,B聚电解质链溶胀.由于蛋白质和B聚电解质链间的静电吸引,导致高分子混合刷对蛋白质的吸附.当A高分子水合性增强时,A高分子链溶胀,B聚电解质链塌缩.由于蛋白质与A高分子链间的排斥作用增强,与B聚电解质链间的静电吸引减弱,混合刷对蛋白质解吸附.

关 键 词:中性/聚电解质高分子混合刷  蛋白质  吸附/解吸附
收稿时间:2019/5/23 0:00:00
修稿时间:2019/6/9 0:00:00

Mixed neutral/polyelectrolyte polymer brushes toward protein adsorption/ desorption
Zhao Xin-Jun,Chen Jiu-Zhi and Ma Chao.Mixed neutral/polyelectrolyte polymer brushes toward protein adsorption/ desorption[J].Journal of Atomic and Molecular Physics,2020,37(2):177-184.
Authors:Zhao Xin-Jun  Chen Jiu-Zhi and Ma Chao
Abstract:Using a molecular theory, we investigate the mixed neutral(A) /polyelectrolyte (B) polymer brushes with switchable properties toward protein adsorption/desorption. Our model takes repulsion interaction between protein and neutral polymer(A), electrostatic attractive interaction between polyelectrolyte (B) and protein, respectly. We found that in the case of and weak hydration of polymer A, the A chains adopt a compact conformation on the bottom of the brush while B chains are highly stretched away from the substrate surface. Because of electrostatic attractive interaction between B and protein, protein adsorption occurs. When the hydration of polymer A increased, the inverse transformation of A and B takes place. Because of increasing repulsion interaction between protein and A, in the same time, decreasing electrostatic attractive interaction between B and protein, the proteins can be released by the mixed brushes.
Keywords:mixed neutral/polyelectrolyte brushes  protein  adsorption/ desorption
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