Development of practical methodologies for the synthesis of novel 3(4-oxo-4H-chromen-3-yl)acrylic acid hydrazides |
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Authors: | Joshi Ratnadeep S Mandhane Priyanka G Badadhe Pravin V Gill Charansingh H |
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Institution: | Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, India. |
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Abstract: | We report a new environmentally-benign, convenient and facile methodology for the synthesis of new series of 3(4-oxo-4H-chromen-3-yl)acrylic acid hydrazides derivatives designed by exploring the molecular hybridization approach between isoniazide and 3(4-oxo-4H-chromen-3-yl)acrylic acids by using EDCl/HOBt under ultrasound irradiation in very short reaction time. Utilization of easy reaction conditions, isolation and purification makes this manipulation very interesting from an economic perspective. |
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