A derating method for therapeutic applications of high intensity focused ultrasound |
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Authors: | O V Bessonova V A Khokhlova M S Canney M R Bailey and L A Crum |
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Institution: | (1) Institute of Clinical Physiology, National Council of Research, c/o Campus Ecotekne, via per Monteroni, Lecce, 73100, Italy;(2) Bioengineering Division, Euro Mediterranean Scientific Biomedical Institute, Brindisi, Italy |
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Abstract: | Current methods of determining high intensity focused ultrasound (HIFU) fields in tissue rely on extrapolation of measurements
in water assuming linear wave propagation both in water and in tissue. Neglecting nonlinear propagation effects in the derating
process can result in significant errors. A new method based on scaling the source amplitude is introduced to estimate focal
parameters of nonlinear HIFU fields in tissue. Focal values of acoustic field parameters in absorptive tissue are obtained
from a numerical solution to a KZK-type equation and are compared to those simulated for propagation in water. Focal wave-forms,
peak pressures, and intensities are calculated over a wide range of source outputs and linear focusing gains. Our modeling
indicates, that for the high gain sources which are typically used in therapeutic medical applications, the focal field parameters
derated with our method agree well with numerical simulation in tissue. The feasibility of the derating method is demonstrated
experimentally in excised bovine liver tissue. |
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