| 生物材料低温保存过程中的温度场模拟 |
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| 引用本文： | 戎森杰,刘宝林,郝保同,闫静文,高志新.生物材料低温保存过程中的温度场模拟[J].低温与超导,2009,37(11). |
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| 作者姓名： | 戎森杰 刘宝林 郝保同 闫静文 高志新 |
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| 作者单位： | 上海理工大学生物系统热科学研究所,上海,200093 |
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| 基金项目： | 教育部新世纪优秀人才计划，国家自然科学基金项目，上海高校东方学者计划资助 |
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| 摘 要： | 低温保存是生物材料进行长时间保存的一种有效方法,但在0℃~-60℃的温区范围,极容易发生低温损伤,如何减小低温损伤是细胞进行成功的低温保存的关键。文中建立了生物组织在低温保存过程中的数学模型,通过ANSYS分析软件,对样品在降温过程中的温度场进行了计算分析和数值模拟,为冷冻造成细胞损伤的研究提供了理论依据。
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| 关 键 词： | 低温保存 低温损伤 生物组织 温度分布 |
Simulation of temperature field in the cryopreservation process of biological materials |
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| Rong Senjie,Liu Baolin,Hao Baotong,Yan Jingwen,Gao Zhixin.Simulation of temperature field in the cryopreservation process of biological materials[J].Cryogenics and Superconductivity,2009,37(11). |
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| Authors: | Rong Senjie Liu Baolin Hao Baotong Yan Jingwen Gao Zhixin |
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| Institution: | Rong Senjie,Liu Baolin,Hao Baotong,Yan Jingwen,Gao Zhixin(University of Shanghai for Science and Technology,Institute of Cryobiology,Shanghai 200093,China) |
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| Abstract: | Cryopreservation is an effective method for the long time preservation of biological materials, but cryo-injury often occurres in the temperature region of 0℃～-60℃, and how to reduce the cryo-injury is important for cells cryopreservation. In this paper, a mathematical model for biological tissue in the preservation was developed, and through the analysis software ANSYS, the calculated analysis and numerical simulation on the distribution of temperature field in cells cooling process were made, which provided a theoretical basis for cells cryo-injury caused by freezing. |
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| Keywords: | Cryopreservation Cryo-injury Biological tissue Temperature distribution |
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