Activation volume vs BOLD signal change as measures of fMRI activation – Its impact on GABA – fMRI activation correlation |
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| Institution: | 1. Imaging Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA;2. Radiology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 9500 Euclid Ave, Cleveland, OH 44195, USA;3. Neurological Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA;1. Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA;2. Clinical Research Core, Office of the Scientific Director, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA;1. Division of Cardiology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA;2. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA;1. Department of Mathematics, University of Bergen, Bergen, Norway;2. Christian Michelsen Research, Bergen, Norway;3. Faculty of Health and Social Sciences, Western Norway University of Applied Sciences, Bergen, Norway;4. Department of Radiology, Haukeland University Hospital, Bergen, Norway;5. Department of Biomedicine, University of Bergen, Bergen, Norway;6. Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway;7. Department of Clinical Medicine, University of Bergen, Bergen, Norway;8. MedViz Research Cluster, University of Bergen, Bergen, Norway;1. Vanderbilt University Institute of Imaging Science, Nashville, TN, United States;2. Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States;3. Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, United States;4. Department of Medical Physics in Radiology, German Cancer Research Center, Germany;5. Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States;6. Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, United States;1. Department of Radiology, Division of Neonatology, University of Groningen and University Medical Center Groningen, Hanzeplein 1, 9713 GZ, The Netherlands;2. Department of Pediatrics, Division of Neonatology, University of Groningen and University Medical Center Groningen, Hanzeplein 1, 9713 GZ, The Netherlands |
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| Abstract: | PurposeTo explore the relative robustness of functional MRI (fMRI) activation volume and blood oxygen level-dependent (BOLD) signal change as fMRI metric, and to study the effect of relative robustness on the correlation between fMRI activation and cortical gamma amino butyric acid (GABA) in healthy controls and patients with multiple sclerosis (MS).MethodsfMRI data were acquired from healthy controls and patients with MS, with the subjects peforming self paced bilateral finger tapping in block design. GABA spectroscopy was performed with voxel placed on the area of maximum activation during fMRI. Activation volume and BOLD signal changes at primary motor cortex (M1), as well as GABA concentration were calculated for each patient.ResultsActivation volume correlated with BOLD signal change in healthy controls, but no such correlation was observed in patients with MS. This difference was likely the result of higher intersubject noise variance in the patient population. GABA concentration correlated with M1 activation volume in patients but not in controls, and did not correlate with any fMRI metric in patients or controls.ConclusionOur data suggest that activation volume is a more robust measure than BOLD signal change in a group with high intersubject noise variance as in patients with MS. Additionally, this study demonstrated difference in correlation behavior between GABA concentration and the 2 fMRI metrics in patients with MS, suggesting that GABA - activation volume correlation is more appropriate measure in the patient group. |
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