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Proton spectroscopy of human stroke: Assessment of transverse relaxation times and partial volume effects in single volume STEAM MRS
Authors:Andrew M Blamire  Glenn D Graham  Douglas L Rothman  James W Prichard  
Institution:

* Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510, USA

Department of Neurology, Yale University, New Haven, CT 06510, USA

Department of Medicine, Yale University, New Haven, CT 06510, USA

Abstract:Proton T2 relaxation times were measured in 13 stroke patients and 13 aged-matched normal subjects at 2.1 T. Spectra were acquired from an 8-cc volume using the STEAM sequence with echo times (TE) of 30.4 ms and 270.0 ms and repetition time of 2.8 s. Transverse relaxation times were estimated using two-point calculations. Percentage volume of infarct in the STEAM voxel was measured on spin-echo MRI encompassing the infarct and correlated with the peak amplitude of N-acetylated compounds (NA). T2 values of NA, creatine, and choline resonances showed no significant difference between patients and controls. T2 for lactate in patients was 780 ± 257 ms, respectively (mean ± SE, n = 7). In stroke patients, high inverse correlation was found between the absolute NA signal and partial volume of normal brain contributing to each spectrum (p < .001, r = 0.97). Together with unchanged T2, this suggests that NAA largely disappears from infarcted tissue within 24 hr postinfarct.
Keywords:Stroke  Magnetic resonance  Proton spectroscopy  Partial volume  Transverse relaxation time  Lactate  N-Acetyl-aspartate
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