Optimization of a transmit/receive surface coil for squirrel monkey spinal cord imaging |
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| Institution: | 1. Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA;2. Department of Radiology, Vanderbilt University, Nashville, TN, USA;3. Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA;4. UCSF/UC Berkeley Joint Graduate Group in Bioengineering, San Francisco, CA, USA;5. State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China;6. Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA;1. Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children''s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA;2. Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Universiteitssingel 40, 6229 ER Maastricht, the Netherlands;3. Department of Pediatrics, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA;4. Department of Radiology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA;5. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 MA Avenue, Cambridge, MA 02139, USA;6. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 MA Avenue, Cambridge, MA 02139, USA;7. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 77 MA Avenue, Cambridge, MA 02139, USA;8. Athinoula A. Martinos Center for Biomedical Imaging, MA General Hospital, 149 13th Street, Charlestown, MA 02129, USA;1. Lauterbur Imaging Research Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China;2. Shenzhen Key Laboratory for MRI, Shenzhen 518055, China;3. Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA;4. UCSF/UC Berkeley Joint Graduate Group in Bioengineering, San Francisco, CA 94158, USA |
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| Abstract: | MR Imaging the spinal cord of non-human primates (NHP), such as squirrel monkey, is important since the injuries in NHP resemble those that afflict human spinal cords. Our previous studies have reported a multi-parametric MRI protocol, including functional MRI, diffusion tensor imaging, quantitative magnetization transfer and chemical exchange saturation transfer, which allows non-invasive detection and monitoring of injury-associated structural, functional and molecular changes over time. High signal-to-noise ratio (SNR) is critical for obtaining high-resolution images and robust estimates of MRI parameters. In this work, we describe our construction and use of a single channel coil designed to maximize the SNR for imaging the squirrel monkey cervical spinal cord in a 21 cm bore magnet at 9.4 T. We first numerically optimized the coil dimension of a single loop coil and then evaluated the benefits of a quadrature design. We then built an optimized coil based on the simulation results and compared its SNR performance with a non-optimized single coil in both phantoms and in vivo. |
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