Synthesis of 5-alkylated barbituric acids and 3-alkylated indoles via microwave-assisted three-component reactions in solvent-free conditions using Hantzsch 1,4-dihydropyridines as reducing agents |
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Authors: | Biswajita Baruah P Seetham Naidu Pallabi Borah Pulak J Bhuyan |
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Institution: | 1. Medicinal Chemistry Division, North East Institute of Science & Technology, Jorhat, 785006, Assam, India
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Abstract: | Reaction of barbituric acids with aldehydes and dihydropyridines in one pot under microwave (MW) irradiation in the absence of solvent, affords 55–82% of the 5-benzylated barbituric acids. Use of alkyl nitriles or barbituric acids with indole-3-aldehyde and dihydropyridine (DHP) afforded 3-alkylated indoles in 57–76 % yield. In each case DHPs are converted to pyridines. |
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