Building 2D classification models and 3D CoMSIA models on small-molecule inhibitors of both wild-type and T790M/L858R double-mutant EGFR |
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| Authors: | Huo Donghui Wang Hongzhao Qin Zijian Tian Yujia Yan Aixia |
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| Institution: | 1.State Key Laboratory of Chemical Resource Engineering, Department of Pharmaceutical Engineering, University of Chemical Technology, Beijing, People’s Republic of China
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| Abstract: | Molecular Diversity - Epidermal growth factor receptor (EGFR) has received widespread attention because it is an important target for anticancer drug design. Mutations in the EGFR, especially the... |
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