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Exploring the cause of the dual allosteric targeted inhibition attaching to allosteric sites enhancing SHP2 inhibition |
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| Authors: | Yangchun Ma WenYu Yang Liang Zhou LiPeng Li JingWei Wu WeiYa Li Shan Du Ying Ma RunLing Wang |
| Institution: | 1.Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China ;2.State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China ; |
| Abstract: | Molecular Diversity - SHP2 is a protein tyrosine phosphatase (PTP) that can regulate the tyrosine phosphorylation level. Overexpression of SHP2 will promote the development of cancer diseases, so... |
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| 本文献已被 SpringerLink 等数据库收录！ | |