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Solution-phase reductive cyclization of 2-quinoxalinol analogs: Systematic study of parallel synthesis |
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| Authors: | Xiang-Hong Wu Gang Liu Jing Zhang Zhan-Guo Wang Song Xu Suo-De Zhang Liang Zhang Lin Wang |
| Institution: | Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, 1 Xian Nong Tan Street, Beijing 100050, PR China. |
| Abstract: | 1,5-Difluoro-2,4-dinitrobenzene starting material was treated via primary and/or secondary substitution with a variety of amino acids or amines and the aromatic m-dinitro groups were then reductively cyclized provide the 2-quinoxalinol analogs. The conditions for 1,5-dialkylamino-2,4-dinitrobenzene reduction have been systematically studied and optimized in solution. Three effective methods are described for the high-throughout generation of 2-quinoxalinol analogs. |
| Keywords: | aromatic nitro reduction m-dinitro benzene parallel synthesis 2-quinoxalinol analog reductive cyclization solution-phase |
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