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Effects of creatine and β-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models |
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| Authors: | Dae Won Kim Seong-Il Yeo Hea Jin Ryu Ji-Eun Kim Hong-Ki Song Oh-Shin Kwon Soo Young Choi and Tae-Cheon Kang |
| Institution: | 1.Department of Biomedical Sciences, College of Life Science,Hallym University,Chunchon,Republic of Korea;2.Department of Anatomy and Neurobiology, College of Medicine,Hallym University,Chunchon,Republic of Korea;3.Institute of Epilepsy Research, College of Medicine, Hallym University,Chunchon,Republic of Korea;4.Department of Neurology, College of Medicine,Hallym University,Chunchon,Republic of Korea;5.Department of Biochemistry, College of Natural Science,Kyungpook National University,Taegu,Republic of Korea |
| Abstract: | BackgroundIn order to confirm the roles of creatine (Cr) in epilepsy, we investigated the anti-convulsive effects of Cr, creatine transporter (CRT) and creatine kinases (CKs) against chemical-induced acute seizure activity and chronic epileptic seizure activity. |
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