Newly generated cells are increased in hippocampus of adult mice lacking a serine protease inhibitor |
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| Authors: | Maddalena M Lino Catherine Vaillant Slobodanka Orolicki Melanie Sticker Mirna Kvajo and Denis Monard |
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| Institution: | (1) Friedrich Miescher Institute for Biomedical Research, Basel, CH-4058, Switzerland;(2) Psychiatric Institute, Department of Psychiatry, Columbia University, New York, NY 10032, USA;(3) Novartis Pharma AG, Klybeckstrasse 141, CH-4057 Basel, Switzerland |
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| Abstract: | Background Neurogenesis in the hippocampal dentate gyrus and the subventricular zone occurs throughout the life of mammals and newly
generated neurons can integrate functionally into established neuronal circuits. Neurogenesis levels in the dentate gyrus
are modulated by changes in the environment (enrichment, exercise), hippocampal-dependent tasks, NMDA receptor (NMDAR) activity,
sonic hedgehog (SHH) and/or other factors. |
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