Physical basis for membrane-charge selectivity of cationic antimicrobial peptides |
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Authors: | Taheri-Araghi Sattar Ha Bae-Yeun |
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Institution: | Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada. |
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Abstract: | Antimicrobial peptides are known to selectively disrupt (highly charged) microbial membranes by asymmetrical incorporation into the outer layers. We present a physical basis for membrane-charge selectivity of cationic antimicrobial peptides. In particular, we provide a clear picture of how peptide-charge Q influences the asymmetrical insertion--one salient feature is the existence of an optimal peptide charge, at which selective insertion is optimized. Our results suggest that large Q is required for antimicrobial selectivity, consistent with experiments. |
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