Monitoring process of human keloid formation based on second harmonic generation imaging |
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Authors: | Jiang X S Chen S Chen J X Zhu X Q Zheng L Q Zhuo S M Wang D J |
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Institution: | 1.Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, 350007, China ;2.Fujian Provincial Dermatology Hospital, Fuzhou, 350009, China ; |
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Abstract: | In this paper, the morphological variation of collagen among the whole dermis from keloid tissue was investigated using second
harmonic generation (SHG) microscopy. In the deep dermis of keloids, collagen bundles show apparently regular gap. In the
middle dermis, the collagen bundles are randomly oriented and loosely arranged in the pattern of fine mesh while the collagen
bundles are organized in a parallel manner in the superficial dermis near the epidermis. The developed parameters COI and
BD can be used to further quantitatively describe these changes. Our results demonstrate the potential of SHG microscopy to
understand the formation process of human keloid scar at the cellular level through imaging collagen variations in different
depth of dermis. |
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