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Optical biopsy of breast cancer tissue |
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| Authors: | M S AlSalhi S Ben Amer K Farhat D Rabah S Devanesan M Atif V Masilamani Reem K S Al-Dakheel |
| Institution: | 1. Research Chair on Laser Diagnosis of Cancers, King Saud University, Riyadh, KSA 4. Department of Physics and Astronomy, King Saud University, College of Science, Riyadh, KSA 2. King Faisal Research Centre, King Faisal Hospital Riyadh, Riyadh, KSA 3. Princess Johara Al-Ibrahim Research Centre for Prostate Cancer, College of Medicine, King Khalid University Hospital, King Saud University Riyadh, Riyadh, KSA 5. Department of Physics and Astronomy, Dammam University, College of Science, Al-Khobar, KSA |
| Abstract: | In this paper, we report results of Fluorescence Emission Spectra (FES) and Stokes Shift Spectra (SSS) of 19 cancer tissue of invasive ductal carcinoma of different grades in comparison with normal breast tissues (obtained away from tumor regions). We were able to get distinct differences in the spectral features of normal and malignant tissues in terms of the ratios of concentrations of biomolecules like tryptophan, collagen and NADH. The sensitivity and specificity were in the range of 75%. What was all the more important was the parallelism in the spectral features of normal and malignant breast tissue pieces of above set of subjects. The objective of our research is to evolve one such protocol and the first step is the spectral characterization of in vitro optical analyses of excised tumor tissues. |
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