Synthesis, DNA-binding, Cytotoxicity, Photo Cleavage, Antimicrobial and Docking Studies of Ru(II) Polypyridyl Complexes |
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| Authors: | A Srishailam Yata Praveen Kumar Nazar M D Gabra P Venkat Reddy N Deepika Nageti Veerababu S Satyanarayana |
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| Institution: | 1. Department of Chemistry, Osmania University, Hyderabad, India, 500007
2. Department of Biochemistry, Osmania University, Hyderabad, India, 500007
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| Abstract: | Three Ruthenium(II) polypyridine complexes, Ru(phen)2(mipc)]2+(1), Ru(bpy)2(mipc)]2+ (2) and Ru(dmb)2(mipc)]2+(3) mipc?=?2-(6-methyl-3-(1H-imidazo4, 5-f]1,10]-phenanthroline-2-yl)-4H-chromene-4-one, phen?=?1,10-phenanthroline,bpy?=?2, 2′bipyridine,dmb?=?4, 4′-dimethyl-2, 2′-bipyridine] have been synthesized and characterized by elemental analysis, IR, UV–Vis, 1H& 13C NMR and mass spectra. The DNA-binding properties of the Ruthenium(II) complexes were investigated by spectrophotometric methods, viscosity measurements and light switch studies. These three complexes have been focused on photo activated cleavage studies with pBR-322 and antimicrobial studies. Experimental results indicate that the three complexes intercalate into DNA base pairs and follows the order of 1?>?2?>?3 respectively. Molecular docking studies also support the DNA interactions with complexes through hydrogen bonding and vander Waal’s interactions. Cytotoxicity studies with Hela cell lines has been revealing about anti tumor activity of these complexes. |
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