Synthesis,Characterization, DNA Binding Properties,Fluorescence Studies and Toxic Activity of Cobalt(III) and Ruthenium(II) Polypyridyl Complexes |
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| Authors: | Penumaka Nagababu Mynam Shilpa J Naveena Lavanya Latha Ira Bhatnagar P N B S Srinivas Yata Praveen Kumar Kotha Laxma Reddy Sirasani Satyanarayana |
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| Institution: | (1) Department of Chemistry, Osmania University, Hyderabad, Andhra Pradesh, India, PIN-500 007;(2) CCMB (Centre for Cellular and Molecular Biology), Hyderabad, 500007, India;(3) National Institute of Nutrition, Hyderabad, India;(4) Department of Biotechnology, Krishna University, Machilipatnam, India; |
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| Abstract: | The new ligand 4-(isopropylbenzaldehyde)imidazo4,5-f ]1,10]phenanthroline (ippip) and its complexes Ru(phen)2(ippip)]2+(1),Co(phen)2(ippip)]3+(2),Ru(bpy)2(ippip)]2+(3),Co(bpy)2(ippip)]3+(4)(bpy=2,2-bipyridine) and (phen=1,10-phenanthroline) were synthesized and characterized by ES+-MS, 1H and 13C NMR. The DNA binding properties of the four complexes were investigated by different spectrophotometric methods and viscosity
measurements. The results suggest that complexes bind to calf thymus DNA (CT-DNA) through intercalation. When irradiated at
365 nm, the complexes promote the photocleavage of pBR322 DNA, and complex 1 cleaves DNA more effectively than 2, 3, 4 complexes
under comparable experimental conditions. Furthermore, photocleavage studies reveal that singlet oxygen (1O2) plays a significant role in the photocleavage. |
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