A Quninolylthiazole Derivatives as an ICT-Based Fluorescent Probe of Hg(II) and its Application in Ratiometric Imaging in Live HeLa Cells |
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| Authors: | Jian-Ying Bai Yu-Zhong Xie Chang-Jiang Wang Shu-Qing Fang Lin-Nan Cao Ling-Li Wang Jing-Yi Jin |
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| Institution: | 1.Research Centre of Chemical Biology,Yanbian University,Yanji,China;2.National Demonstration Centre for Experimental Chemistry Education (Yanbian University), Department of Chemistry,Yanbian University,Yanji,China;3.College of Chemistry,Northeast Normal University,Changchun,China;4.Department of Nephrology,The Central Hospital of Jiamusi,Jiamusi,China |
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| Abstract: | As a structural analogue of pyridylthiazole, 2-(2-benzothiazoyl)-phenylethynylquinoline (QBT) was designed as a fluorescent probe for Hg(II) based on an intramolecular charge transfer (ICT) mechanism. The compound was synthesized in three steps starting from 6-bromo-2-methylquinoline, with moderate yield. Corresponding studies on the optical properties of QBT indicate that changes in the fluorescence ratio of QBT in response to Hg(II) could be quantified based on dual-emission changes. More specifically, the emission spectrum of QBT before and after interactions with Hg(II) exhibited a remarkable red shift of about 120 nm, which is rarely reported in ICT-based fluorescent sensors. Finally, QBT was applied in the two-channel imaging of Hg(II) in live HeLa cells. |
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