2,6-Dansyl Azide as a Fluorescent Probe for Hydrogen Sulfide |
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| Authors: | Ke Wang Hanjing Peng Nanting Ni Chaofeng Dai Binghe Wang |
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| Institution: | 1. Department of Chemistry, Center for Diagnostics and Therapeutics, and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA, 30302-4098, USA
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| Abstract: | A second-generation sulfonyl azide-based fluorescent probe, 2,6-DNS-Az, has been developed for the quantitative detection of H2S in aqueous media such as phosphate buffer and bovine serum. Compare to the first-generation 1,5-DNS-Az probe, this probe shows both high sensitivity in phosphate buffer without the need for addition of surfactant and selectivity for sulfide over other anions and biomolecules, and thus can be used as a useful tool for detection of H2S in the biological system. |
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