P-coumaric acid-zinc basic salt nanohybrid for controlled release and sustained antioxidant activity |
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Authors: | Timothy Biswick Yong-Gun Shul |
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Institution: | a Center for Intelligent NanoBio Materials (CINBM), Department of Bioinspired Science and Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea b Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Republic of Korea |
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Abstract: | P-coumaric acid (pCA) has been intercalated in zinc basic salt (ZBS) to design an organic-inorganic nanohybrid material with controlled release and sustained antioxidant activity. According to the powder X-ray diffraction patterns and FT-IR spectra, pCA molecules were intercalated into ZBS without any noticeable alterations in their structural integrity. In vitro release test showed a biphasic discharge of pCA out of the interlayer space of two-dimensional ZBS lattice consisting of an initial burst release followed by a slow and sustained release. The pCA-ZBS nanohybrid exhibited comparable antioxidant activity to that of the free pCA. |
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Keywords: | A Nanostructures |
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