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| 基于核磁共振弹性成像技术的肝纤维化分级体模研究 | |
| 引用本文： | 汪红志,许凌峰,俞捷,黄清明,王晓琰,陆伦,王鹤,黄勇,程红岩,张学龙,李鲠颖.基于核磁共振弹性成像技术的肝纤维化分级体模研究[J].物理学报,2010,59(10):7463-7471. |
| 作者姓名： | 汪红志 许凌峰 俞捷 黄清明 王晓琰 陆伦 王鹤 黄勇 程红岩 张学龙 李鲠颖 |
| 作者单位： | 1. 华东师范大学物理系,上海市磁共振重点实验室,上海200062;上海理工大学医学影像工程研究所,上海200093;上海医疗器械高等专科学校,上海200093 2. 上海理工大学医学影像工程研究所,上海,200093 3. 上海理工大学医学影像工程研究所,上海200093;上海医疗器械高等专科学校,上海200093 4. 第二军医大学附属东方肝胆医院,上海,200438 5. 通用电器医疗系统,中国,有限公司,上海201203 6. 华东师范大学物理系,上海市磁共振重点实验室,上海200062 |
| 基金项目： | 上海市科研创新基金(批准号:10YZ237)和上海市教育高地建设项目科研基金(批准号:P0502)资助的课题. |
| 摘 要： | 肝纤维化程度以及纤维化速率的精确判断对于相应治疗手术的选择以及治疗预后评估都是至关重要的.临床上需要发展一种非侵入性的肝纤维化定量检查手段.核磁共振弹性成像技术成为实现肝纤维化分级研究的最具发展前景的技术之一.我们研制开发了可用于进行肝纤维化分级研究的实验平台,并讨论了激励装置和位移相位成像序列的技术细节,最后给出了体模的初步实验结果并对结果进行了分析.为后续体模深入研究和临床应用实验奠定基础. |
| 关 键 词： | 核磁共振弹性成像 肝纤维化 体模 剪切波 |
| 收稿时间： | 2009-10-30 |
Phantom study of the classification of liver fibrosis based on nuclear magnetic resonance elasto-graphy |
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| Wang Hong-Zhi,Xu Lin-Feng,Yu Jie,Huang Qing-Ming,Wang Xiao-Yan,Lu Lun,Wang He,Huang Yong,Cheng Hong-Yan,Zhang Xue-Long,Li Geng-Ying.Phantom study of the classification of liver fibrosis based on nuclear magnetic resonance elasto-graphy[J].Acta Physica Sinica,2010,59(10):7463-7471. | |
| Authors: | Wang Hong-Zhi Xu Lin-Feng Yu Jie Huang Qing-Ming Wang Xiao-Yan Lu Lun Wang He Huang Yong Cheng Hong-Yan Zhang Xue-Long Li Geng-Ying |
| Institution: | Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China; Institute of Medical Imaging Technology, University of Shanghai Science and Technology, Shanghai 200093, China; Shanghai Medical In;Institute of Medical Imaging Technology, University of Shanghai Science and Technology, Shanghai 200093, China;Institute of Medical Imaging Technology, University of Shanghai Science and Technology, Shanghai 200093, China;Institute of Medical Imaging Technology, University of Shanghai Science and Technology, Shanghai 200093, China; Shanghai Medical Instrumentation College, Shanghai 200093, China;Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China;Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China;GE Healthcare (China), Shanghai 201203, China;Institute of Medical Imaging Technology, University of Shanghai Science and Technology, Shanghai 200093, China; Shanghai Medical Instrumentation College, Shanghai 200093, China;Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China;Institute of Medical Imaging Technology, University of Shanghai Science and Technology, Shanghai 200093, China; Shanghai Medical Instrumentation College, Shanghai 200093, China;Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China |
| Abstract: | Accurate detection of liver fibrosis stage and fibrosis procession is crucial for assessing prognosis and candidacy for treatment of patients with chronic hepatic disease. A significant need exists for developing a noninvasive technique for quantitative detection of liver fibrosis stage. Magnetic resonance elasto-graphy (MRE) is one of the most repidly advancing technologies for classifying the liver fibrosis. This study establishes a platform for liver fibrosis classification, and discusses some details in developing stimulator and displacement-phase imaging pulse. At last, the preliminary result and analysis of phantom experiment are given, which would form a basis for subsequent research on phantom MRE and its clinic application. |
| Keywords: | magnetic resonance elasto-graphy liver fibrosis phantom shear wave |
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