DNA损伤致p53-Mdm2相互作用的动力学模型

最新实验结果表明，在受到各种辐射而引起DNA损伤后，在单体细胞和群体细胞情况下，细胞中的p53蛋白浓度表现为非衰减振荡和衰减振荡两种不同的动力学行为.通过研究p53-Mdm2负反馈回路的非线性动力学行为，分析了各种(特别是DNA损伤、p53和 Mdm2蛋白浓度三者之间)动力学关系，提出了一个能同时描述这两种不同动力学行为的非线性模型. 关键词： p53-Mdm2负反馈回路 非衰减振荡和衰减振荡 非线性动力学模型

A dynamical model of DNA-damage derived p53-Mdm2 interaction

The recent experiments on the dynamics of a common biological network motif, p53-Mdm2 feedback loop in population and individual cells shows two different kinds of oscillatory behaviors, namely the damped and sustained oscillations, for the activities of p53 and Mdm2 proteins in response to DNA damage. By exploiting the nonlinear dynamics in the negative feedback loop and through analyzing the dynamical relation between the DNA damage and the activities of p53 and Mdm2 proteins, we propose a nonlinear dynamical model to describe the oscillatory behaviors for the activities of p53 and Mdm2 proteins both in individual and in population of cells in a self-consistent and unified way.