生物钟基因网络中分子噪声诱导的日夜节律振荡及相干共振

研究了果蝇细胞内生物钟基因调节网络的分子噪声，特别讨论了生物钟系统处于略微远离振荡区域的稳态时分子噪声对于时钟蛋白的日夜节律振荡的影响.结果表明：(1)虽然时钟蛋白合成或者衰减的生化反应事件是在随机的时间间隔里随机发生的，但系统可以依赖自身固有的调节机理诱导出明显的日夜节律振荡；(2)分子噪声诱导的日夜节律振荡的相干性可以在合适的分子噪声水平下到达最佳，说明了相干共振现象的发生. 关键词： 生物钟 分子噪声 日夜节律振荡 相干共振

Molecular noise induced circadian oscillation and coherence resonance in the gene network of biological clock

The molecular noise in the gene regulation network of biological clock in Drosophila was studied. Especially, we investigated the effect of molecular noise on the circadian rhythmic oscillation when the system is in the steady state region but only slightly away from the oscillating region. We show that (i) Though the prodution and the decay of the protein are stochastic with the stochastic time interval, the obvious circadian oscillation can be induced depending on the system intrinsic regulation mechanism. (ii) The coherence of molecular noise-induced oscillation is optimal under an appropriate molecular noise level, leading to the occurrence of coherence resonance.