光声内窥镜系统在人体直肠癌离体组织中的实验研究

研制了基于4阵列传感器的光声内窥镜探头,并基于此搭建了光声内窥镜成像系统,开展了仿体实验成像研究,通过内窥镜探头4个阵元位置激光吸收强度的变化情况来分析仿体中吸收体的位置,论证了其定位能力,利用光声内窥镜系统对人体离体的正常组织、直肠癌早期组织进行成像研究;通过对不同阵元位置的光吸收强度分布进行统计分析,证明了光声内窥镜对早期直肠癌组织和正常组织的辨别能力,此项技术有望提高直肠癌早期诊断的准确率,具有潜在的临床应用前景。

The human colorectal cancer tissue in vitro experimental study based on photoacoustic endoscopic system

This paper developed a 4 array transducers photoacoustic endoscopic probe, and based on this, a photoacoustic endoscopic imaging system was build. Phantom experimental imaging was carried out, and the capability of location for endoscopic probe was demonstrated via analyzing the absorption of the light on the 4 sensors position. The in vitro human normal tissues and early colorectal cancer tissues was imaged using photoacoustic endoscopic system. The statistical analysis of the light absorbtion intensity distribution on different position proved that the photoacoustic endoscopic system has the ability to distinguish human normal tissues and early colorectal cancer tissues. This technology is expected to improve the accuracy of early diagnosis of colorectal cancer and has the potential clinical application.
Keywords： transducer photoacoustic endoscopy colorectal cancer