| 用小角X射线散射法和31P核磁共振技术研究蓖麻酸对磷脂胆固醇混合脂质体液晶态结构的影响 |
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| 引用本文： | 孙润广,张静,戴正华,徐逢勋,王德华.用小角X射线散射法和31P核磁共振技术研究蓖麻酸对磷脂胆固醇混合脂质体液晶态结构的影响[J].物理学报,1994,43(4):616-621. |
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| 作者姓名： | 孙润广 张静 戴正华 徐逢勋 王德华 |
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| 作者单位： | 陕西师范大学实验中心,西安710062;中国科学院理论物理研究所,北京100080 |
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| 基金项目： | 中关村分析测试基金资助的课题. |
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| 摘 要： | 采用小角X射线散射法和31P核磁共振技术研究了蓖麻酸对磷脂酰乙醇胺和胆固醇混合脂质体液晶态结构的影响,实验结果表明:蓖麻酸对磷脂胆固醇混合脂质体结构有稳定作用。在含有高效分散剂的磷酸盐缓冲溶液中制成的液晶态蓖麻酸多相脂质体由立方六角相构成。
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| 关 键 词： | 磷脂 胆固醇 蓖麻酸 生物膜 |
| 收稿时间： | 1993-01-27 |
A STUDY FOR THE INFLUENCE OF RICINOLEIC ACID ON THE LIQUID CRYSTAL STRUCTURE IN THE MIXED PHOSPHOLIPID CHOLESTEROL LIPOSOMES BY MEANS OF SAXS AND 31P-NMR |
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| SUN RUN-GUANG,ZHANG JING,DAI ZHENG-HUA,XU FENG-XUN and WANG DE-HUA.A STUDY FOR THE INFLUENCE OF RICINOLEIC ACID ON THE LIQUID CRYSTAL STRUCTURE IN THE MIXED PHOSPHOLIPID CHOLESTEROL LIPOSOMES BY MEANS OF SAXS AND 31P-NMR[J].Acta Physica Sinica,1994,43(4):616-621. |
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| Authors: | SUN RUN-GUANG ZHANG JING DAI ZHENG-HUA XU FENG-XUN and WANG DE-HUA |
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| Abstract: | This report presents the results on the investigation of the effect of ricionoleic acid on the structures of the liquid crystal state of mixed phospholipid-cholesterol liposomes by means of the Small Angle X-ray Scattering (SAXS) and 31P Nuclear Magnetism Resomance(31P-NMR). The study shows that the ricinoleic acid helps to stabilize the structure of the mixed phospholipid-cholesterol liposomes and that the polyphase liposome with ricinoleic acid prepared from phosphoric buffer solution containing polyvinylpyrrolidone (PVP) is in the cubic-hexagonal phase. |
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