| 果蝇昼夜生理节律之细胞质PER-TIM间隔定时器的大聚合物模型 |
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| 引用本文： | 张志强,李丛鑫,谢平,王鹏业.果蝇昼夜生理节律之细胞质PER-TIM间隔定时器的大聚合物模型[J].物理学报,2012,61(19):198701-198701. |
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| 作者姓名： | 张志强 李丛鑫 谢平 王鹏业 |
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| 作者单位： | 中国科学院物理研究所,软物质物理重点实验室,北京凝聚态物理国家实验室,北京100190 |
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| 基金项目： | 国家自然科学基金(批准号: 10834014, 10974248) 和国家重点基础研究发展计划 (973计划)(批准号: 2009CB930704)资助的课题. |
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| 摘 要： | 昼夜生理节律使得生物体的生理和行为能够适应外界环境的昼夜循环变化. 实验发现在果蝇的细胞质中存在由PER-TIM复合体组成的间隔计时器. 本文提出了这个间隔定时器的一种可能的数学模型. 模型的特点是大聚合物, 快速交换, 不同磷酸化位点有不同功能. 模拟结果基本与实验相符, 符合PER-TIM间隔定时器的主要时间特征并重现了perL 变异细胞系中定时器的特点, 以及PER和TIM蛋白进入细胞核的三种不同类型的过程.
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| 关 键 词： | PER-TIM生物钟 间隔计时器 翻译后调控 |
| 收稿时间： | 2011-12-27 |
A big cluster model of the PER-TIM interval timer in drosophila cytoplasm for the circadian clock |
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| Zhang Zhi-Qiang,Li Cong-Xin,Xie Ping,Wang Peng-Ye.A big cluster model of the PER-TIM interval timer in drosophila cytoplasm for the circadian clock[J].Acta Physica Sinica,2012,61(19):198701-198701. |
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| Authors: | Zhang Zhi-Qiang Li Cong-Xin Xie Ping Wang Peng-Ye |
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| Institution: | Key Laboratory of Soft Matter Physics, Beijing National Laborartory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Science, Beijing 100190, China |
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| Abstract: | Circadian rhythm makes physiology and behaviors of organisms adapt to the day and night cycle in the environment. Recent experiment indicated a PER-TIM interval timer in Drosophila melanogaster cytoplasm. In this paper, we present a possible mathematical model for this interval timer. The characters of the model are the formation of big clusters, fast exchange and different functions of phosphorylation of different sites. The experimental results on features of the PER-TIM interval timer of mild type and perL mutant and on the existence of three different types of temporal profiles of nuclear accumulation of PER and TIM in single cells are reproduced by our simulations. |
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| Keywords: | PER-TIM circadian clock interval timer post-translational regulation |
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