| Applying the reference-wavelength method to improve the precision of glucose measurement by near infrared spectroscopy |
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| 作者姓名： | 陈文亮 徐可欣 李宇 陈韵 |
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| 作者单位： | State Key Laboratory of Precision Measuring Technology and Instrument Tianjin University，Tianjin 300072，State Key Laboratory of Precision Measuring Technology and Instrument，Tianjin University，Tianjin 300072，State Key Laboratory of Precision Measuring Technology and Instrument，Tianjin University，Tianjin 300072，State Key Laboratory of Precision Measuring Technology and Instrument，Tianjin University，Tianjin 300072 |
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| 基金项目： | This work was supported by the National Key Project of Scientific and Technical Supporting Programs of China(No.2006BAI03A03)，the National Natural Science Foundation of China(No.30600126)，the Postdoc-toral Science Foundation of China(No.20060390661). |
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| 摘 要： | The reference-wavelength method is proposed to diminish the influence of noises on glucose measurement by differentially processing two signals at the reference and measuring wavelengths.At the reference wavelength,the radiation intensity is insensitive to the changes of glucose concentration.Therefore,it can be used as the internal reference to estimate the noise and then to extract the effective glucose signal at the other wavelengths.The validation experiments are constructed in the non-scattering samples with the reference wavelength of glucose at 1525 nm.The results show that the reference-wavelength-based glucose-specific signal extracting method can largely improve the glucose prediction precision from 17.56 to 8.87mg/dL in the two-component experiment and from 26.82 to 9.94 mg/dL in the three-component experiment.
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